Cosmetic surgery is entering a new era where personalization is not just about selecting procedures but tailoring treatments to the patient’s unique biology. Advances in genomics, artificial intelligence (AI), and regenerative medicine are allowing surgeons to design interventions that align with an individual’s genetic blueprint, healing capacity, and lifestyle. Instead of standardized techniques, surgeons are now able to predict how each patient will respond to anesthesia, tissue regeneration, and even scarring. AI-driven planning platforms integrate genomic sequencing, 3D imaging, and patient data to simulate outcomes before a single incision is made. This predictive power not only enhances precision but also minimizes risks, making procedures safer and more effective. By merging genetic data with regenerative innovations like stem cells, exosomes, and growth factors, cosmetic surgery is moving toward scarless healing and naturally harmonious results that look and feel authentic.